The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias.
Cells
; 9(3)2020 02 26.
Article
em En
| MEDLINE
| ID: mdl-32110991
ABSTRACT
The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer. Both proteins are essential regulators of cell proliferation, apoptosis, and differentiation, and they, directly and indirectly, regulate each other's activity. Studies in cancer suggest that targeting the MYC/PP2A network is an achievable strategy for the clinic. Here, we focus on and discuss the role of MYC and PP2A in myeloid leukemias.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide
/
Proteínas Proto-Oncogênicas c-myc
/
Progressão da Doença
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Proteína Fosfatase 2
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cells
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos