METTL14 suppresses proliferation and metastasis of colorectal cancer by down-regulating oncogenic long non-coding RNA XIST.

Yang, Xiao; Zhang, Sen; He, Changyu; Xue, Pei; Zhang, Luyang; He, Zirui; Zang, Lu; Feng, Bo; Sun, Jing; Zheng, Minhua

Yang, Xiao; Zhang, Sen; He, Changyu; Xue, Pei; Zhang, Luyang; He, Zirui; Zang, Lu; Feng, Bo; Sun, Jing; Zheng, Minhua.

Afiliação

Yang X; Division of Gastrointestinal and Colorectal Surgery, Ruijin Hospital, Department of General Surgery, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Zhang S; Shanghai Institute of Minimally Invasive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
He C; Division of Gastrointestinal and Colorectal Surgery, Ruijin Hospital, Department of General Surgery, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Xue P; Shanghai Institute of Minimally Invasive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Zhang L; Division of Gastrointestinal and Colorectal Surgery, Ruijin Hospital, Department of General Surgery, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
He Z; Division of Gastrointestinal and Colorectal Surgery, Ruijin Hospital, Department of General Surgery, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Zang L; Shanghai Institute of Minimally Invasive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Feng B; Division of Gastrointestinal and Colorectal Surgery, Ruijin Hospital, Department of General Surgery, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Sun J; Shanghai Institute of Minimally Invasive Surgery, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.
Zheng M; Division of Gastrointestinal and Colorectal Surgery, Ruijin Hospital, Department of General Surgery, Shanghai Jiao Tong University, School of Medicine, Shanghai, 200001, China.

Mol Cancer ; 19(1): 46, 2020 02 28.

Article em En | MEDLINE | ID: mdl-32111213

Assuntos

Biomarcadores Tumorais/metabolismo; Neoplasias Colorretais/patologia; Regulação Neoplásica da Expressão Gênica; Neoplasias Hepáticas/secundário; Metiltransferases/metabolismo; RNA Longo não Codificante/genética; Animais; Apoptose; Biomarcadores Tumorais/genética; Proliferação de Células; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Feminino; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Metiltransferases/genética; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Prognóstico; Taxa de Sobrevida; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Colorectal cancer; Long non-coding RNA; METTL14; RNA epigenetics; m6A

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / RNA Longo não Codificante / Neoplasias Hepáticas / Metiltransferases Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Mol Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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