Antiexudative Effects of Finasteride and a New Pyrazolo[C]Pyridine Derivative GIZh-72 in Acetic Acid-Induced Experimental Peritonitis.
Bull Exp Biol Med
; 168(4): 453-456, 2020 Feb.
Article
em En
| MEDLINE
| ID: mdl-32146626
ABSTRACT
It was shown that finasteride, a 5α-reductase inhibitor (50 mg/kg, intraperitoneally) produced analgesic and antiexudative effects in experimental peritonitis induced by intraperitoneal injection of 1% acetic acid. These results agree with published data on its anti-inflammatory properties and ability to potentiate the analgesic effect of morphine in rodents. New pyrazolo[C] pyridine derivative GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,3-dihydro-1H-pyrazolo[4,3-C]pyridine-3-on, chloral hydrate) injected intraperitoneally in doses of 20-80 mg/kg produced dose-dependent antiexudative effects, but exhibited no analgesic properties.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peritonite
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Pirazóis
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Piridinas
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Finasterida
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Inibidores de 5-alfa Redutase
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Anti-Inflamatórios
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Federação Russa