Birth weight, childhood body mass index and height and risks of endometriosis and adenomyosis.
Ann Hum Biol
; 47(2): 173-180, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-32151170
ABSTRACT
Background:
Body size in adult life is likely associated with risks of endometriosis and adenomyosis, yet little is known about associations with body size earlier in life.Aim:
To examine whether birth weight, childhood body mass index (BMI) and height are associated with risks of endometriosis and adenomyosis.Subjects andmethods:
From the Copenhagen School Health Records Register, 171,447 girls born 1930-1996, with measured weights and heights at ages 7-13 were included. Outcomes were obtained from health registers. Cox regressions were performed to estimate hazard ratios (HR) and 95% confidence intervals (CI).Results:
During follow-up, 2149 endometriosis cases and 1410 adenomyosis cases were diagnosed. Childhood BMI was inversely associated with endometriosis (HR = 0.92 [95% CI 0.88-0.96] per z-score at age 7). In contrast, childhood height was positively associated with endometriosis (HR = 1.09 [95% CI 1.05-1.14] per z-score at age 7). Associations with childhood body size did not differ by endometriosis location. Childhood BMI and height had limited associations with adenomyosis. Birth weight was not associated with endometriosis or adenomyosis.Conclusion:
Lean and tall girls are more often diagnosed with endometriosis, but not adenomyosis. These findings suggest that indicators of endometriosis risk are already apparent at early ages.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peso ao Nascer
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Estatura
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Índice de Massa Corporal
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Endometriose
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Adenomiose
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Middle aged
/
Newborn
País/Região como assunto:
Europa
Idioma:
En
Revista:
Ann Hum Biol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Dinamarca