The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques.

Webb, Gabriela M; Molden, Jhomary; Busman-Sahay, Kathleen; Abdulhaqq, Shaheed; Wu, Helen L; Weber, Whitney C; Bateman, Katherine B; Reed, Jason S; Northrup, Mina; Maier, Nicholas; Tanaka, Shiho; Gao, Lina; Davey, Brianna; Carpenter, Benjamin L; Axthelm, Michael K; Stanton, Jeffrey J; Smedley, Jeremy; Greene, Justin M; Safrit, Jeffrey T; Estes, Jacob D; Skinner, Pamela J; Sacha, Jonah B

Webb, Gabriela M; Molden, Jhomary; Busman-Sahay, Kathleen; Abdulhaqq, Shaheed; Wu, Helen L; Weber, Whitney C; Bateman, Katherine B; Reed, Jason S; Northrup, Mina; Maier, Nicholas; Tanaka, Shiho; Gao, Lina; Davey, Brianna; Carpenter, Benjamin L; Axthelm, Michael K; Stanton, Jeffrey J; Smedley, Jeremy; Greene, Justin M; Safrit, Jeffrey T; Estes, Jacob D; Skinner, Pamela J; Sacha, Jonah B.

Afiliação

Webb GM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Molden J; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Busman-Sahay K; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America.
Abdulhaqq S; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Wu HL; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Weber WC; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Bateman KB; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Reed JS; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Northrup M; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Maier N; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Tanaka S; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Gao L; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Davey B; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Carpenter BL; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Axthelm MK; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Stanton JJ; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Smedley J; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Greene JM; Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Safrit JT; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Estes JD; ImmunityBio, Los Angeles, California, United States of America.
Skinner PJ; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, United States of America.
Sacha JB; Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, United States of America.

PLoS Pathog ; 16(3): e1008339, 2020 03.

Article em En | MEDLINE | ID: mdl-32163523

Assuntos

Antirretrovirais/administração & dosagem; Linfócitos B/efeitos dos fármacos; Linfócitos T CD8-Positivos/efeitos dos fármacos; Infecções por HIV/tratamento farmacológico; Interleucina-15/antagonistas & inibidores; Células Matadoras Naturais/efeitos dos fármacos; Proteínas/administração & dosagem; Animais; Linfócitos B/citologia; Linfócitos B/imunologia; Linfócitos T CD8-Positivos/citologia; Linfócitos T CD8-Positivos/imunologia; Movimento Celular/efeitos dos fármacos; Modelos Animais de Doenças; Infecções por HIV/genética; Infecções por HIV/imunologia; Infecções por HIV/fisiopatologia; HIV-1/efeitos dos fármacos; HIV-1/fisiologia; Humanos; Interleucina-15/genética; Interleucina-15/imunologia; Células Matadoras Naturais/citologia; Células Matadoras Naturais/imunologia; Linfonodos/efeitos dos fármacos; Linfonodos/imunologia; Macaca mulatta; Proteínas Recombinantes de Fusão; Síndrome de Imunodeficiência Adquirida dos Símios/tratamento farmacológico; Síndrome de Imunodeficiência Adquirida dos Símios/imunologia; Síndrome de Imunodeficiência Adquirida dos Símios/fisiopatologia; Síndrome de Imunodeficiência Adquirida dos Símios/virologia; Vírus da Imunodeficiência Símia/efeitos dos fármacos; Vírus da Imunodeficiência Símia/fisiologia; Latência Viral/efeitos dos fármacos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Células Matadoras Naturais / Proteínas / Infecções por HIV / Linfócitos T CD8-Positivos / Interleucina-15 / Antirretrovirais Limite: Animals / Humans Idioma: En Revista: PLoS Pathog Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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