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The "Far Left" of the Morphologic Spectrum of Ovarian High-grade Serous Carcinoma: Case Report of a Purely Noninvasive High-grade Serous Carcinoma Mimicking an Ovarian Serous Borderline Tumor.
Int J Gynecol Pathol ; 40(2): 175-179, 2021 Mar 01.
Article em En | MEDLINE | ID: mdl-32168063
High-grade serous carcinoma has a variety of different growth patterns, but is typically easily recognizable to pathologists and rarely confused with serous borderline tumors. We report a case of a 71-yr-old woman with a unilateral 5.1 cm ovarian cyst with small papillary projections on contrast-enhanced magnetic resonance imaging of the pelvis. Histologic examination showed a noninvasive papillary neoplasm with hierarchical branching and epithelial proliferation, and thus, at low magnification, bearing a striking resemblance to a serous borderline tumor. However, a more careful examination demonstrated high-grade cytologic features, nuclear pleomorphism, and abundant mitotic activity, suggestive of high-grade serous carcinoma. The morphology and immunohistochemical profile of this lesion is consistent with a rare, purely noninvasive growth pattern of high-grade serous carcinoma. This lesion represents the "far left" of the high-grade ovarian serous carcinoma morphologic spectrum and can mimic a serous borderline tumor.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cistos Ovarianos / Neoplasias Ovarianas / Cistadenocarcinoma Seroso / Neoplasias Epiteliais e Glandulares Limite: Aged / Female / Humans Idioma: En Revista: Int J Gynecol Pathol Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cistos Ovarianos / Neoplasias Ovarianas / Cistadenocarcinoma Seroso / Neoplasias Epiteliais e Glandulares Limite: Aged / Female / Humans Idioma: En Revista: Int J Gynecol Pathol Ano de publicação: 2021 Tipo de documento: Article