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Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines.
Boon, Ruben; Kumar, Manoj; Tricot, Tine; Elia, Ilaria; Ordovas, Laura; Jacobs, Frank; One, Jennifer; De Smedt, Jonathan; Eelen, Guy; Bird, Matthew; Roelandt, Philip; Doglioni, Ginevra; Vriens, Kim; Rossi, Matteo; Vazquez, Marta Aguirre; Vanwelden, Thomas; Chesnais, François; El Taghdouini, Adil; Najimi, Mustapha; Sokal, Etienne; Cassiman, David; Snoeys, Jan; Monshouwer, Mario; Hu, Wei-Shou; Lange, Christian; Carmeliet, Peter; Fendt, Sarah-Maria; Verfaillie, Catherine M.
Afiliação
  • Boon R; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium. rboon@mgh.harvard.edu.
  • Kumar M; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Tricot T; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Elia I; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
  • Ordovas L; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Jacobs F; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • One J; Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Aragón Institute of Engineering Research, IIS Aragón University of Zaragoza, Aragon I + D Foundation (ARAID), Zaragoza, Spain.
  • De Smedt J; Janssen Research and Development, Beerse, Belgium.
  • Eelen G; Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA.
  • Bird M; Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA.
  • Roelandt P; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Doglioni G; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.
  • Vriens K; Laboratory of Angiogenesis and Vascular Metabolism, Center of Cancer Biology, VIB, Leuven, Belgium.
  • Rossi M; Hepatology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
  • Vazquez MA; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Vanwelden T; Hepatology, Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium.
  • Chesnais F; Translational Research in GastroIntestinal Disorders (TARGID), Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), KU Leuven, Leuven, Belgium.
  • El Taghdouini A; Department of Gastroenterology and Hepatology, UZ Leuven, Leuven, Belgium.
  • Najimi M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
  • Sokal E; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Cassiman D; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
  • Snoeys J; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Monshouwer M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB Center for Cancer Biology, VIB, Leuven, Belgium.
  • Hu WS; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
  • Lange C; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Carmeliet P; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Fendt SM; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Verfaillie CM; Laboratory of Pediatric Hepatology and Cell Therapy, Universit Catholique de Louvain & Cliniques Universitaires St Luc, Institut de Recherche Clinique et Expérimentale (IREC), Brussels, Belgium.
Nat Commun ; 11(1): 1393, 2020 03 13.
Article em En | MEDLINE | ID: mdl-32170132
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Hepatócitos / Sistema Enzimático do Citocromo P-450 / Aminoácidos / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Hepatócitos / Sistema Enzimático do Citocromo P-450 / Aminoácidos / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bélgica