Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy.
J Alzheimers Dis
; 74(4): 1189-1201, 2020.
Article
em En
| MEDLINE
| ID: mdl-32176643
ABSTRACT
BACKGROUND:
There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-ß (Aß) cerebral amyloid angiopathy (CAA).OBJECTIVE:
To determine the profile of biomarkers relevant to neurodegenerative disease in the CSF of patients with CAA.METHODS:
We performed a detailed comparison of CSF markers, comparing patients with CAA, Alzheimer's disease (AD), and control (CS) participants, recruited from the Biomarkers and Outcomes in CAA (BOCAA) study, and a Specialist Cognitive Disorders Service.RESULTS:
We included 10 CAA, 20 AD, and 10 CS participants (mean age 68.6, 62.5, and 62.2 years, respectively). In unadjusted analyses, CAA patients had a distinctive CSF biomarker profile, with significantly lower (pâ<â0.01) median concentrations of Aß38, Aß40, Aß42, sAßPPα, and sAßPPß. CAA patients had higher levels of neurofilament light (NFL) than the CS group (pâ<â0.01), but there were no significant differences in CSF total tau, phospho-tau, soluble TREM2 (sTREM2), or neurogranin concentrations. AD patients had higher total tau, phospho-tau and neurogranin than CS and CAA groups. In age-adjusted analyses, differences for the CAA group remained for Aß38, Aß40, Aß42, and sAßPPß. Comparing CAA patients with amyloid-PET positive (nâ=â5) and negative (nâ=â5) scans, PET positive individuals had lower (pâ<â0.05) concentrations of CSF Aß42, and higher total tau, phospho-tau, NFL, and neurogranin concentrations, consistent with an "AD-like" profile.CONCLUSION:
CAA has a characteristic biomarker profile, suggestive of a global, rather than selective, accumulation of amyloid species; we also provide evidence of different phenotypes according to amyloid-PET positivity. Further replication and validation of these preliminary findings in larger cohorts is needed.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Angiopatia Amiloide Cerebral
Tipo de estudo:
Observational_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Alzheimers Dis
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido