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FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles.
Ricklefs, Franz L; Maire, Cecile L; Matschke, Jakob; Dührsen, Lasse; Sauvigny, Thomas; Holz, Mareike; Kolbe, Katharina; Peine, Sven; Herold-Mende, Christel; Carter, Bob; Chiocca, E Antonio; Lawler, Sean E; Westphal, Manfred; Lamszus, Katrin.
Afiliação
  • Ricklefs FL; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Maire CL; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Matschke J; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Dührsen L; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Sauvigny T; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Holz M; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Kolbe K; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Peine S; Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Herold-Mende C; Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany.
  • Carter B; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  • Chiocca EA; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Lawler SE; Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Westphal M; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
  • Lamszus K; Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Int J Mol Sci ; 21(6)2020 Mar 12.
Article em En | MEDLINE | ID: mdl-32178271
ABSTRACT
Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Biomarcadores Tumorais / Ácido Graxo Sintase Tipo I / Vesículas Extracelulares / Glioma Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Biomarcadores Tumorais / Ácido Graxo Sintase Tipo I / Vesículas Extracelulares / Glioma Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha