C6-ceramide induces salivary adenoid cystic carcinoma cell apoptosis via IP3R-activated UPR and UPR-independent pathways.

Qiu, Ling; Liu, Zhe; Wu, Chenzhou; Chen, Wen; Chen, Yafei; Zhang, Bowen; Li, Jinjin; Liu, Huabing; Huang, Nengwen; Jiang, Zhou; Wu, Yongzhi; Li, Longjiang

Qiu, Ling; Liu, Zhe; Wu, Chenzhou; Chen, Wen; Chen, Yafei; Zhang, Bowen; Li, Jinjin; Liu, Huabing; Huang, Nengwen; Jiang, Zhou; Wu, Yongzhi; Li, Longjiang.

Afiliação

Qiu L; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Liu Z; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Wu C; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Chen W; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Chen Y; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Zhang B; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Li J; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Liu H; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Huang N; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Jiang Z; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Wu Y; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro
Li L; Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Ro

Biochem Biophys Res Commun ; 525(4): 997-1003, 2020 05 14.

Article em En | MEDLINE | ID: mdl-32178876

Assuntos

Apoptose/efeitos dos fármacos; Carcinoma Adenoide Cístico/metabolismo; Ceramidas/farmacologia; Retículo Endoplasmático/metabolismo; Receptores de Inositol 1,4,5-Trifosfato/metabolismo; Neoplasias das Glândulas Salivares/metabolismo; Resposta a Proteínas não Dobradas/efeitos dos fármacos; Animais; Apoptose/genética; Cálcio/metabolismo; Carcinoma Adenoide Cístico/genética; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/genética; Ceramidas/administração & dosagem; Citosol/efeitos dos fármacos; Citosol/metabolismo; Retículo Endoplasmático/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/genética; Inativação Gênica; Humanos; Receptores de Inositol 1,4,5-Trifosfato/genética; Antígeno Ki-67/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Membranas Mitocondriais/metabolismo; Análise de Sequência com Séries de Oligonucleotídeos; Neoplasias das Glândulas Salivares/genética; Transdução de Sinais/genética; Resposta a Proteínas não Dobradas/genética; Ensaios Antitumorais Modelo de Xenoenxerto; eIF-2 Quinase/genética; eIF-2 Quinase/metabolismo

Palavras-chave

Apoptosis; Ceramide; Inositol 1,4,5-trisphosphate receptor; Mitochondria outer membrane permeabilization; Unfolded protein response

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias das Glândulas Salivares / Ceramidas / Apoptose / Carcinoma Adenoide Cístico / Retículo Endoplasmático / Receptores de Inositol 1,4,5-Trifosfato / Resposta a Proteínas não Dobradas Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google