Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-&#954;B signaling pathway and pyroptosis after secondary spinal cord injury.

Liu, Zhongyuan; Yao, Xinqiang; Jiang, Wangsheng; Li, Wei; Zhu, Siyuan; Liao, Congrui; Zou, Lin; Ding, Ruoting; Chen, Jianting

Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury.

Liu, Zhongyuan; Yao, Xinqiang; Jiang, Wangsheng; Li, Wei; Zhu, Siyuan; Liao, Congrui; Zou, Lin; Ding, Ruoting; Chen, Jianting.

Afiliação

Liu Z; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Yao X; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Jiang W; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Li W; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Zhu S; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Liao C; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Zou L; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Ding R; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. ding_ruoting@163.com.
Chen J; Department of Spinal Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China. chenjt99@tom.com.

J Neuroinflammation ; 17(1): 90, 2020 Mar 20.

Article em En | MEDLINE | ID: mdl-32192500

Assuntos

Produtos da Oxidação Avançada de Proteínas/metabolismo; Microglia/metabolismo; Estresse Oxidativo/fisiologia; Piroptose/fisiologia; Traumatismos da Medula Espinal/metabolismo; Produtos da Oxidação Avançada de Proteínas/farmacologia; Animais; Linhagem Celular; Inflamação/metabolismo; Inflamação/patologia; Inflamação/fisiopatologia; Sistema de Sinalização das MAP Quinases/fisiologia; Masculino; Camundongos; Microglia/efeitos dos fármacos; Microglia/patologia; NF-kappa B/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Piroptose/efeitos dos fármacos; Ratos; Ratos Sprague-Dawley; Traumatismos da Medula Espinal/patologia; Traumatismos da Medula Espinal/fisiopatologia

Palavras-chave

Advanced oxidation protein products; Inflammatory response; MAPKs-NF-κB signaling pathway; NLRP3-mediated pyroptosis; ROS-dependent; Spinal cord injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Microglia / Estresse Oxidativo / Produtos da Oxidação Avançada de Proteínas / Piroptose Limite: Animals Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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