"Somatostatinoma": a somatostatin-containing tumor of the endocrine pancreas.
N Engl J Med
; 296(17): 963-7, 1977 Apr 28.
Article
em En
| MEDLINE
| ID: mdl-321960
ABSTRACT
We studied the pancreatic and enteric hormone profile of a 46-year-old woman who had hyperglycemia and a pancreatic tumor. Before operation, there was no evidence of overproduction of glucagon or insulin. The tumor's ultrastructure had a distinctive endocrine morphology, resembling D cells. Prompted by the recent demonstration of somatostatin in D cells of pancreatic islets, we analyzed the tumor and found a large quantity of immunoreactive somatostatin (301 ng per milligram of tissue). Insulin, glucagon, gastrin, vasoactive intestinal polypeptide and human pancreatic polypeptide were present in only trace quantities. The tumor cells were cultured in monolayers, which remained viable up to 51 days and released somatostatin into the culture medium. In seven insulinomas and two glucagonomas, we found the somatostatin content either much lower (less than 0.6 ng per milligram of tissue) or undetectable. After complete resection of the tumor, our patient became euglycemic and has remained so for the past 20 months.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Somatostatina
/
Ilhotas Pancreáticas
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
N Engl J Med
Ano de publicação:
1977
Tipo de documento:
Article