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Polyphenols composition from leaves of Cuphea spp. and inhibitor potential, in vitro, of angiotensin I-converting enzyme (ACE).
Santos, Marí C; Toson, Natally S B; Pimentel, Maria C B; Bordignon, Sérgio A L; Mendez, Andreas S L; Henriques, Amélia T.
Afiliação
  • Santos MC; Pharmacognosy Laboratory, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: mari.santos@ufrgs.br.
  • Toson NSB; Pharmacognosy Laboratory, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Brazil.
  • Pimentel MCB; Keizo-Asami Immunopathology Laboratory, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
  • Bordignon SAL; Department of Environmental Impact Assessment, Unilasalle, Canoas, Rio Grande do Sul, Brazil.
  • Mendez ASL; Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
  • Henriques AT; Pharmacognosy Laboratory, Faculty of Pharmacy, Federal University of Rio Grande do Sul, Brazil; Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
J Ethnopharmacol ; 255: 112781, 2020 Jun 12.
Article em En | MEDLINE | ID: mdl-32209389
ETHNOPHARMACOLOGICAL RELEVANCE: Cuphea is the largest genus of the Lythraceae family. It is popularly known as "sete-sangrias" in Brazil used in folk medicine as a diuretic, antipyretic, anti-inflammatory, laxative and antihypertensive agent. The raw material of Cuphea has shown promising results in the production of fitotherapics, which are chemically characterized by quercetin core flavonoids. AIMS OF THE STUDY: Present work aims to investigate the chemical composition of Cuphea calophylla, Cuphea carthagenensis, Cuphea glutinosa and Cuphea racemosa by UHPLC-MS using ESI-Q-TOF, and also to investigate the inhibition of angiotensin-converting enzyme (ACE) in vitro. MATERIALS AND METHODS: Leaves extraction was conducted by an ultrasound-assisted system under the following conditions: 40% ethanol, particle size ≤180 µm, plant:solvent ratio 1:20 (w/v) for 30 min. The leaf extracts were analyzed by UHPLC-MS positive mode ionization. For the inhibition of ACE, the leaf extracts used were obtained from different Cuphea species collected from several regions of Rio Grande do Sul (Brazil). RESULTS: In total 26 polyphenolic compounds were proposed, which were mostly derived from quercetin, myricetin, and kaempferol. Of these compounds, ten are described in the genus for the first time. The ACE-inhibiting activities are presented in descending order: miquelianin (32.41%), C. glutinosa 1 (31.66%), C. glutinosa 5 (26.32%) and C. carthagenensis 1 (26.12%). CONCLUSION: The obtained results suggest that the ACE-inhibiting potential may be increased by the interactions among the different phytoconstituents present in the crude extract. These results corroborate with the popular usage of Cuphea genus as diuretic and antihypertensive agents in folk medicine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Enzima Conversora de Angiotensina / Extratos Vegetais / Peptidil Dipeptidase A / Folhas de Planta / Cuphea / Polifenóis / Pulmão Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Enzima Conversora de Angiotensina / Extratos Vegetais / Peptidil Dipeptidase A / Folhas de Planta / Cuphea / Polifenóis / Pulmão Limite: Animals Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2020 Tipo de documento: Article