Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.

Kumar, Sandeep; Singh, Sunil Kumar; Viswakarma, Navin; Sondarva, Gautam; Nair, Rakesh Sathish; Sethupathi, Periannan; Sinha, Subhash C; Emmadi, Rajyasree; Hoskins, Kent; Danciu, Oana; Thatcher, Gregory R J; Rana, Basabi; Rana, Ajay

Kumar, Sandeep; Singh, Sunil Kumar; Viswakarma, Navin; Sondarva, Gautam; Nair, Rakesh Sathish; Sethupathi, Periannan; Sinha, Subhash C; Emmadi, Rajyasree; Hoskins, Kent; Danciu, Oana; Thatcher, Gregory R J; Rana, Basabi; Rana, Ajay.

Afiliação

Kumar S; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612.
Singh SK; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612.
Viswakarma N; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612.
Sondarva G; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612.
Nair RS; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612.
Sethupathi P; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612.
Sinha SC; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065.
Emmadi R; Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612.
Hoskins K; Division of Hematology/Oncology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612.
Danciu O; Division of Hematology/Oncology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612.
Thatcher GRJ; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612.
Rana B; Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL 60612.
Rana A; University of Illinois Hospital and Health Sciences System Cancer Center, University of Illinois at Chicago, Chicago, IL 60612.

Proc Natl Acad Sci U S A ; 117(14): 7961-7970, 2020 04 07.

Article em En | MEDLINE | ID: mdl-32209667

Assuntos

Neoplasias da Mama/imunologia; Linfócitos do Interstício Tumoral/imunologia; MAP Quinase Quinase Quinases/metabolismo; Neoplasias Mamárias Experimentais/imunologia; Linfócitos T Citotóxicos/imunologia; Animais; Neoplasias da Mama/sangue; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/patologia; Linhagem Celular Tumoral/transplante; Ciclofilina A/metabolismo; Feminino; Humanos; Ativação Linfocitária/efeitos dos fármacos; Linfócitos do Interstício Tumoral/efeitos dos fármacos; Linfócitos do Interstício Tumoral/metabolismo; MAP Quinase Quinase Quinases/antagonistas & inibidores; MAP Quinase Quinase Quinases/genética; Neoplasias Mamárias Experimentais/sangue; Neoplasias Mamárias Experimentais/patologia; Camundongos; Fatores de Transcrição NFATC/metabolismo; Fosforilação/efeitos dos fármacos; Fosforilação/imunologia; Cultura Primária de Células; Inibidores de Proteínas Quinases/farmacologia; Inibidores de Proteínas Quinases/uso terapêutico; Piridinas/farmacologia; Piridinas/uso terapêutico; Pirróis/farmacologia; Pirróis/uso terapêutico; Linfócitos T Citotóxicos/efeitos dos fármacos; Linfócitos T Citotóxicos/metabolismo; Evasão Tumoral/efeitos dos fármacos; MAP Quinase Quinase Quinase 11 Ativada por Mitógeno

Palavras-chave

CD8+ T cell; MLK3; T cell activation; breast cancer; cytotoxic T cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Linfócitos T Citotóxicos / Linfócitos do Interstício Tumoral / MAP Quinase Quinase Quinases / Neoplasias Mamárias Experimentais Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

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