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Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction.
Sakaue, Saori; Hirata, Jun; Kanai, Masahiro; Suzuki, Ken; Akiyama, Masato; Lai Too, Chun; Arayssi, Thurayya; Hammoudeh, Mohammed; Al Emadi, Samar; Masri, Basel K; Halabi, Hussein; Badsha, Humeira; Uthman, Imad W; Saxena, Richa; Padyukov, Leonid; Hirata, Makoto; Matsuda, Koichi; Murakami, Yoshinori; Kamatani, Yoichiro; Okada, Yukinori.
Afiliação
  • Sakaue S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
  • Hirata J; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Kanai M; Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, 113-8655, Japan.
  • Suzuki K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
  • Akiyama M; Pharmaceutical Discovery Research Laboratories, TEIJIN PHARMA LIMITED, Hino, 191-8512, Japan.
  • Lai Too C; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
  • Arayssi T; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Hammoudeh M; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA.
  • Al Emadi S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
  • Masri BK; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
  • Halabi H; Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, 812-8582, Japan.
  • Badsha H; Allergy and Immunology Research Center, Institute for Medical Research, Ministry of Health Malaysia, 40170, Setia Alam, Malaysia.
  • Uthman IW; Division of Rheumatology, Department of Medicine, Karolinska Institutet and Karolinska University Hospital, 17177, Stockholm, Sweden.
  • Saxena R; Department of Internal Medicine, Weill Cornell Medicine-Qatar, Education City, Doha, 24144, Qatar.
  • Padyukov L; Department of Internal Medicine, Hamad Medical Corporation, Doha, 3050, Qatar.
  • Hirata M; Department of Internal Medicine, Hamad Medical Corporation, Doha, 3050, Qatar.
  • Matsuda K; Department of Internal Medicine, Jordan Hospital, Amman, 520248, Jordan.
  • Murakami Y; Rheumatology Division, Department of Internal Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, H45X+P6, Saudi Arabia.
  • Kamatani Y; Dr. Humeira Badsha Medical Center, Emirates Hospital, Dubai, 391203, United Arab Emirates.
  • Okada Y; Department of Rheumatology, American University of Beirut, Beirut, 11-0236, Lebanon.
Nat Commun ; 11(1): 1569, 2020 03 26.
Article em En | MEDLINE | ID: mdl-32218440
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Herança Multifatorial / Povo Asiático / Redução Dimensional com Múltiplos Fatores / Genética Populacional Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / Herança Multifatorial / Povo Asiático / Redução Dimensional com Múltiplos Fatores / Genética Populacional Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão