Outbreak Severity of Highly Pathogenic Avian Influenza A(H5N8) Viruses Is Inversely Correlated to Polymerase Complex Activity and Interferon Induction.

Vigeveno, René M; Poen, Marjolein J; Parker, Edyth; Holwerda, Melle; de Haan, Karen; van Montfort, Thijs; Lewis, Nicola S; Russell, Colin A; Fouchier, Ron A M; de Jong, Menno D; Eggink, Dirk

Vigeveno, René M; Poen, Marjolein J; Parker, Edyth; Holwerda, Melle; de Haan, Karen; van Montfort, Thijs; Lewis, Nicola S; Russell, Colin A; Fouchier, Ron A M; de Jong, Menno D; Eggink, Dirk.

Afiliação

Vigeveno RM; Department of Medical Microbiology, Amsterdam UMC, Amsterdam, the Netherlands.
Poen MJ; Department of Viroscience, Erasmus MC, Rotterdam, the Netherlands.
Parker E; Department of Medical Microbiology, Amsterdam UMC, Amsterdam, the Netherlands.
Holwerda M; Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
de Haan K; Department of Medical Microbiology, Amsterdam UMC, Amsterdam, the Netherlands.
van Montfort T; Department of Medical Microbiology, Amsterdam UMC, Amsterdam, the Netherlands.
Lewis NS; Department of Medical Microbiology, Amsterdam UMC, Amsterdam, the Netherlands.
Russell CA; OIE/FAO International Reference Laboratory for Avian Influenza, Swine Influenza and Newcastle Disease, Animal and Plant Health Agency (APHA)-Weybridge, Addlestone, Surrey, United Kingdom.
Fouchier RAM; Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, Hertfordshire, United Kingdom.
de Jong MD; Department of Medical Microbiology, Amsterdam UMC, Amsterdam, the Netherlands.
Eggink D; Department of Viroscience, Erasmus MC, Rotterdam, the Netherlands.

J Virol ; 94(11)2020 05 18.

Article em En | MEDLINE | ID: mdl-32238581

Assuntos

Proteínas Aviárias; Surtos de Doenças; Vírus da Influenza A Subtipo H5N8; Influenza Aviária; Interferon beta; RNA Polimerase Dependente de RNA; Proteínas Virais; Animais; Proteínas Aviárias/genética; Proteínas Aviárias/imunologia; Coturnix; Cães; Patos; Células HEK293; Humanos; Vírus da Influenza A Subtipo H5N8/genética; Vírus da Influenza A Subtipo H5N8/imunologia; Influenza Aviária/epidemiologia; Influenza Aviária/genética; Influenza Aviária/imunologia; Interferon beta/genética; Interferon beta/imunologia; Células Madin Darby de Rim Canino; RNA Polimerase Dependente de RNA/genética; RNA Polimerase Dependente de RNA/imunologia; Proteínas Virais/genética; Proteínas Virais/imunologia

Palavras-chave

H5N8; influenza virus; interferon; polymerase complex; virology; virulence

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Virais / RNA Polimerase Dependente de RNA / Surtos de Doenças / Interferon beta / Proteínas Aviárias / Vírus da Influenza A Subtipo H5N8 / Influenza Aviária Limite: Animals / Humans Idioma: En Revista: J Virol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda

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