Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control.
Org Lett
; 22(8): 3128-3134, 2020 Apr 17.
Article
em En
| MEDLINE
| ID: mdl-32239959
ABSTRACT
An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key to success of the title reaction was the equilibrium control by adjusting the ratio of the resolving reagent, and unique enantiodivergence was observed depending on the equilibrium displacement.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Japão