Poikilocytosis in the acne vulgaris comorbidity with demodicosis and functional gallbladder disorder.

OBJECTIVE: The aim of the study was to evaluate the role of poikilocytosis in the acne vulgaris comorbidity with demodicosis and functional gallbladder disorder. PATIENTS AND METHODS: Materials and methods: The study included 140 people with a diagnosis of moderate acne: group 1 - patients with AV, group 2 - patients with AV + Demodicosis, group3- AV + Demodicosis + functional gallbladder disorder (FGD). Biochemical analysis of lipid profile and liver enzymes, bilirubin was performed with semi-automatic analyzer HUMALYZER 3000. Scanning electron microscopy was performed using scanning electron microscope PEI-106I "SELMI". Ultrasound investigation was carried out by the SonoScape S6Pro US-diagnostic system with 3 - 5 MHz Ultrasound Probe Transducer С354. RESULTS: Results: The most significant changes in blood erythrocytes morphology were observed in patients with comorbidity of acne, demodicosis and FGD with highest increasing of deformed erythrocytes up to 21%, mainly due to echinocytes І, ІІ order. Correlation analysis has revealed a strong direct association r = +0.75 (p < 0.05) between the poikilocytosis and comorbidity of acne vulgaris with demodicosis and FGD. CONCLUSION: Conclusions: A strong direct association between acne vulgaris comorbid pathology and the increased number of deformation shapes of erythrocytes confirms the impact of FGD on morphological characteristics of erythrocytes and developing of poikilocytosis.