Safety and efficacy of tranexamic acid in children with cerebral palsy undergoing femoral varus derotational osteotomy: a double cohort study.
Eur J Orthop Surg Traumatol
; 30(6): 1039-1044, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32253597
ABSTRACT
AIMS:
The safety and efficacy of tranexamic acid (TXA) in reducing blood loss after total joint arthroplasty and spinal fusion surgery has been well documented. However, little data exist regarding the effectiveness of intraoperative TXA in children with cerebral palsy (CP). The aim of this double cohort study is to investigate the safety and efficacy of intraoperative TXA in reducing blood loss and transfusion requirements for children with CP undergoing a proximal unilateral or bilateral femoral varus derotational osteotomy (VDRO). PATIENTS ANDMETHODS:
A retrospective review was performed of all paediatric theatre lists between May 2012 and January 2019 for all paediatric (< 16 years old) CP patients who underwent unilateral or bilateral VDRO combined with soft tissue release at our institution. Fifty-one patients were included in our study further subdivided into two individual groups, unilateral and bilateral VDRO.RESULTS:
No statistically significant differences were found in demographics such as age, weight, ASA, GMFCS and antiepileptic medication between the groups. However, there were significant statistically differences in TBL and transfusion rates between the groups that received TXA and those that did not, both in unilateral [241 ml (TXA) vs. 369 ml (non-TXA)] and bilateral [287 ml (TXA) vs. 467 ml (non-TXA)] operations.CONCLUSION:
TXA successfully reduced TBL (in both TXA subgroups) and the transfusion rates without associated complications. TXA's safety and efficacy should be explored further in adequately powered randomized controlled trials.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteotomia
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Ácido Tranexâmico
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Perda Sanguínea Cirúrgica
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Coxa Vara
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Eur J Orthop Surg Traumatol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido