Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review.
Aging Dis
; 11(2): 378-389, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-32257548
ABSTRACT
Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Aging Dis
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China