Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia.

Rahman, Rahana Abd; Murthi, Padma; Singh, Harmeet; Gurungsinghe, Seshini; Leaw, Bryan; Mockler, Joanne C; Lim, Rebecca; Wallace, Euan M

Rahman, Rahana Abd; Murthi, Padma; Singh, Harmeet; Gurungsinghe, Seshini; Leaw, Bryan; Mockler, Joanne C; Lim, Rebecca; Wallace, Euan M.

Afiliação

Rahman RA; Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia.
Murthi P; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.
Singh H; Department of Obstetrics and Gynaecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur 56000, Malaysia.
Gurungsinghe S; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.
Leaw B; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria 3052, Australia.
Mockler JC; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.
Lim R; Department of Obstetrics and Gynaecology, School of Clinical Sciences, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia.
Wallace EM; The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria 3168, Australia.

Int J Mol Sci ; 21(7)2020 Apr 03.

Article em En | MEDLINE | ID: mdl-32260307

Assuntos

Dinoprosta/análogos & derivados; Células Endoteliais da Veia Umbilical Humana/citologia; Hidroxicloroquina/farmacologia; Placenta/efeitos dos fármacos; Pré-Eclâmpsia/metabolismo; Hipóxia Celular; Sobrevivência Celular/efeitos dos fármacos; Dinoprosta/metabolismo; Endoglina/metabolismo; Feminino; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Subunidades beta de Inibinas/metabolismo; Modelos Biológicos; Placenta/metabolismo; Pré-Eclâmpsia/tratamento farmacológico; Gravidez; Fator de Necrose Tumoral alfa/metabolismo; Receptor 1 de Fatores de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

TNF-α; endothelial dysfunction; hydroxychloroquine; preeclampsia; sEng; sFlt-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Pré-Eclâmpsia / Dinoprosta / Células Endoteliais da Veia Umbilical Humana / Hidroxicloroquina Tipo de estudo: Prognostic_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Austrália

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