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Hazards of Recurrence, Second Primary, or Other Tumor at Ten Years After Surgery for Non-Small-Cell Lung Cancer.
Fink-Neuboeck, Nicole; Lindenmann, Joerg; Porubsky, Christian; Fediuk, Melanie; Anegg, Udo; Maier, Alfred; Smolle, Josef; Lamont, Eugenia; Smolle-Juettner, Freyja Maria.
Afiliação
  • Fink-Neuboeck N; Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
  • Lindenmann J; Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria. Electronic address: jo.lindenmann@medunigraz.at.
  • Porubsky C; Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
  • Fediuk M; Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
  • Anegg U; Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
  • Maier A; Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
  • Smolle J; Institute of Medical Informatics, Statistics, and Documentation, Medical University of Graz, Graz, Austria.
  • Lamont E; Section for Surgical Research, Department of Surgery, Medical University of Graz, Graz, Austria.
  • Smolle-Juettner FM; Division of Thoracic Surgery and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Graz, Austria.
Clin Lung Cancer ; 21(4): 333-340, 2020 07.
Article em En | MEDLINE | ID: mdl-32273257
INTRODUCTION: Better treatment options entail the risk of multiple tumors in a patient's lifetime. We studied the incidence, risk factors, and prognostic impact of second primaries and other malignancies in patients with operated non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: We retrospectively analyzed 342 consecutive patients with curatively resected NSCLC between 2003 and 2007. RESULTS: Among the 342 patients analyzed, 172 (50.3%) developed locoregional and/or distant recurrence; 25 (7.3%) had a second primary lung cancer, 97 (28.3%) had 1 or more malignancies other than NSCLC either in their history (n = 61; 17.8%) or following resection (n = 64; 18.7%). One hundred fifteen patients (33.6%) had a malignancy other than primary NSCLC. Eight patients developed both a second primary lung cancer and another malignancy. Older age and lower N-stage were significantly correlated with the occurrence of an additional tumor, as shown by a logistic regression nomogram. Whereas the risk of recurrence decreases over time, the risk of developing a second tumor, particularly a second primary lung cancer, remains high during up to 10 years of follow-up. One hundred seventy patients (49.7%) died of the primary (n = 158; 46.2%) or second primary (n = 12; 3.5%) NSCLC, 23 (6.7%) died of another malignancy, and 66 (19.3%) died due to unrelated causes (overall 10-year survival, 33.3%). CONCLUSIONS: Second primary lung cancer or other malignancy occurs in 33% of patients with NSCLC; 26% of patients are affected within 10 years after resection of lung cancer. With curative treatment of secondary tumors, there is no negative influence on long-term prognosis of NSCLC; therefore, follow-up beyond 5 years is strongly advisable.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonectomia / Carcinoma de Células Escamosas / Segunda Neoplasia Primária / Carcinoma Pulmonar de Células não Pequenas / Adenocarcinoma de Pulmão / Neoplasias Pulmonares / Recidiva Local de Neoplasia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Clin Lung Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Áustria

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonectomia / Carcinoma de Células Escamosas / Segunda Neoplasia Primária / Carcinoma Pulmonar de Células não Pequenas / Adenocarcinoma de Pulmão / Neoplasias Pulmonares / Recidiva Local de Neoplasia Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Clin Lung Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Áustria