The rise of T-type channels in melanoma progression and chemotherapeutic resistance.
Biochim Biophys Acta Rev Cancer
; 1873(2): 188364, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32275934
ABSTRACT
Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the BRAF and NRAS genes. MAPK inhibitors are effective only short-term, and recurrence occurs due to functional redundancies or intertwined pathways. The remodeling of Ca2+ signaling is also common in melanoma cells, partly through the increased expression of T-type channels (TTCCs). Here we summarize current knowledge about the prognostic value and molecular targeting of TTCCs. Furthermore, we discuss recent evidence pointing to TTCCs as molecular switches for melanoma chemoresistance, which set the grounds for novel combined therapies against the advanced disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Sistema de Sinalização das MAP Quinases
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Canais de Cálcio Tipo T
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Melanoma
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Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta Rev Cancer
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Espanha