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The Novel In Vitro Method to Calculate Tissue-to-Plasma Partition Coefficient in Humans for Predicting Pharmacokinetic Profiles by Physiologically-Based Pharmacokinetic Model With High Predictability.
Mayumi, Kei; Tachibana, Miho; Yoshida, Mei; Ohnishi, Shuichi; Kanazu, Takushi; Hasegawa, Hiroshi.
Afiliação
  • Mayumi K; Research Laboratory for Development, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561-0825, Japan. Electronic address: kei.mayumi@shionogi.co.jp.
  • Tachibana M; Analytical Chemistry & Bioanalysis, Shionogi TechnoAdvance Research Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Yoshida M; Drug Safety, DMPK & Drug Efficacy Evaluation, Shionogi TechnoAdvance Research Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Ohnishi S; Research Laboratory for Development, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Kanazu T; Research Laboratory for Development, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
  • Hasegawa H; Research Laboratory for Development, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
J Pharm Sci ; 109(7): 2345-2355, 2020 07.
Article em En | MEDLINE | ID: mdl-32283068
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasma / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: J Pharm Sci Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Plasma / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: J Pharm Sci Ano de publicação: 2020 Tipo de documento: Article