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Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches.
Wu, Feng-Jie; Williams, Lisa M; Abdul-Ridha, Alaa; Gunatilaka, Avanka; Vaid, Tasneem M; Kocan, Martina; Whitehead, Alice R; Griffin, Michael D W; Bathgate, Ross A D; Scott, Daniel J; Gooley, Paul R.
Afiliação
  • Wu FJ; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3052, VIC, Australia; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville 3052, VIC, Australia; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Pa
  • Williams LM; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3052, VIC, Australia.
  • Abdul-Ridha A; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3052, VIC, Australia.
  • Gunatilaka A; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3052, VIC, Australia.
  • Vaid TM; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3052, VIC, Australia; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville 3052, VIC, Australia; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Pa
  • Kocan M; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3052, VIC, Australia.
  • Whitehead AR; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3052, VIC, Australia.
  • Griffin MDW; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3052, VIC, Australia; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville 3052, VIC, Australia.
  • Bathgate RAD; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3052, VIC, Australia; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3052, VIC, Australia.
  • Scott DJ; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3052, VIC, Australia; The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville 3052, VIC, Australia. Electronic address: daniel.scott@florey.edu.au.
  • Gooley PR; Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3052, VIC, Australia; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville 3052, VIC, Australia. Electronic address: prg@unimelb.edu.au.
J Biol Chem ; 295(21): 7404-7417, 2020 05 22.
Article em En | MEDLINE | ID: mdl-32303636
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos alfa 1 Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Panamá
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos alfa 1 Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Panamá