Targeting inducible costimulator expressed on CXCR5+PD-1+ TH cells suppresses the progression of pemphigus vulgaris.

Kim, A Reum; Han, Dawoon; Choi, Ji Young; Seok, Joon; Kim, Song-Ee; Seo, Seong-Hoon; Takahashi, Hayato; Amagai, Masayuki; Park, Su-Hyung; Kim, Soo-Chan; Shin, Eui-Cheol; Kim, Jong Hoon

Targeting inducible costimulator expressed on CXCR5⁺PD-1⁺ T_H cells suppresses the progression of pemphigus vulgaris.

Kim, A Reum; Han, Dawoon; Choi, Ji Young; Seok, Joon; Kim, Song-Ee; Seo, Seong-Hoon; Takahashi, Hayato; Amagai, Masayuki; Park, Su-Hyung; Kim, Soo-Chan; Shin, Eui-Cheol; Kim, Jong Hoon.

Afiliação

Kim AR; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Han D; Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Choi JY; Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Seok J; Laboratory of Translational Immunology and Vaccinology, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Kim SE; Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Seo SH; Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Takahashi H; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Amagai M; Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Park SH; Laboratory of Translational Immunology and Vaccinology, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Kim SC; Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address: kimsc@yuhs.ac.
Shin EC; Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea. Electronic address: ecshin@kaist.ac.kr.
Kim JH; Department of Dermatology and Cutaneous Biology Research Institute, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address: jhkim074@yuhs.ac.

J Allergy Clin Immunol ; 146(5): 1070-1079.e8, 2020 11.

Article em En | MEDLINE | ID: mdl-32311391

Assuntos

Anti-Inflamatórios/uso terapêutico; Anticorpos Bloqueadores/uso terapêutico; Desmogleína 3/metabolismo; Centro Germinativo/imunologia; Proteína Coestimuladora de Linfócitos T Induzíveis/metabolismo; Pênfigo/terapia; Células Th1/metabolismo; Animais; Autoanticorpos/metabolismo; Desmogleína 3/genética; Modelos Animais de Doenças; Progressão da Doença; Citometria de Fluxo; Humanos; Memória Imunológica; Proteína Coestimuladora de Linfócitos T Induzíveis/imunologia; Camundongos; Camundongos Knockout; Pênfigo/imunologia; Receptor de Morte Celular Programada 1/metabolismo; Receptores CXCR5/metabolismo; Células Th1/imunologia

Palavras-chave

T follicular helper cell; desmoglein; humoral immunity; inducible costimulator; pemphigus vulgaris

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pênfigo / Células Th1 / Centro Germinativo / Anticorpos Bloqueadores / Desmogleína 3 / Proteína Coestimuladora de Linfócitos T Induzíveis / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2020 Tipo de documento: Article

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