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Melanoma-associated fibroblasts impair CD8+ T cell function and modify expression of immune checkpoint regulators via increased arginase activity.
Érsek, Barbara; Silló, Pálma; Cakir, Ugur; Molnár, Viktor; Bencsik, András; Mayer, Balázs; Mezey, Eva; Kárpáti, Sarolta; Pós, Zoltán; Németh, Krisztián.
Afiliação
  • Érsek B; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary.
  • Silló P; Office for Research Groups Attached to Universities and Other Institutions of the Hungarian Academy of Sciences, Budapest, 1051, Hungary.
  • Cakir U; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
  • Molnár V; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
  • Bencsik A; Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, 1083, Hungary.
  • Mayer B; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary.
  • Mezey E; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
  • Kárpáti S; National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20815, USA.
  • Pós Z; Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, 1085, Hungary.
  • Németh K; Department of Genetics, Cell and Immunobiology, Semmelweis University, 4 Nagyvarad ter, VII/709, Budapest, 1089, Hungary. pos.zoltan@med.semmelweis-univ.hu.
Cell Mol Life Sci ; 78(2): 661-673, 2021 Jan.
Article em En | MEDLINE | ID: mdl-32328671
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arginase / Neoplasias Cutâneas / Linfócitos T CD8-Positivos / Fibroblastos Associados a Câncer / Proteínas de Checkpoint Imunológico / Melanoma Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Hungria
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arginase / Neoplasias Cutâneas / Linfócitos T CD8-Positivos / Fibroblastos Associados a Câncer / Proteínas de Checkpoint Imunológico / Melanoma Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Hungria