Non-cryopreserved peripheral blood stem cells autologous transplantation in multiple myeloma: Bicentric study.
Transfus Clin Biol
; 27(3): 152-156, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32334934
ABSTRACT
OBJECTIVES:
The objective of this study is to evaluate the toxicity of autologous transplantation of non-frozen peripheral blood stem cells in Moroccan patients with multiple myeloma. MATERIAL ANDMETHODS:
This was a bicentric retrospective study conducted in the Clinical Haematology Department of Mohammed V Military Teaching Hospital and at the Al Madina Clinic in Casablanca. The study period was from January 2015 to June 2019. All patients with multiple myeloma who had undergone an autologous peripheral stem cell transplant without freezing were included. Mobilisation was performed with lenograstim alone and the collected stem cells were stored for 24-48hours in a blood bank refrigerator at a temperature of 4°C. After standard conditioning with high-dose melphalan, the peripheral blood stem cells were reinjected 24 h following conditioning.RESULTS:
Over the study period, 55 patients received an autologous transplant using non-frozen peripheral blood stem cells. The median richness of the CD34 cells collected was 4.5×106 CD34/kg (range 2-12.2). The time required for neutrophil recovery was 12 days (range 7-19). The time required for platelet recovery was 14 days (range 9-32). The mortality rate within 100 days post-transplant was 3.6%. We did not observe any cases of graft failure.CONCLUSION:
Our study finds good feasibility and low toxicity of autologous peripheral stem cell transplantation without freezing in patients with multiple myeloma.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Preservação de Sangue
/
Transplante de Células-Tronco de Sangue Periférico
/
Mieloma Múltiplo
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Africa
Idioma:
En
Revista:
Transfus Clin Biol
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article