Management of Endophthalmitis with and without Topical Antibiotics: A Case-Control Study.
Ophthalmologica
; 244(3): 208-212, 2021.
Article
em En
| MEDLINE
| ID: mdl-32335557
ABSTRACT
PURPOSE:
The aim of this study was to compare the management outcome of endophthalmitis with and without the use of topical antibiotics.METHODS:
A retrospective comparative chart review of 2 cohorts of endophthalmitis (other than those associated with open-globe injury, keratitis, or wound site infection), one managed with topical antibiotics (TA group) and one without (NTA group), was performed.RESULTS:
The study included a total of 270 eyes of 270 patients. Of these, 169 eyes were in the TA group and 101 were in the NTA group. Post-cataract surgery was the most common etiology, accounting for 81.06 and 78.2% of cases, respectively (p = 0.57). A favorable functional outcome at the last visit was seen in 37.5 and 39.6% of eyes (p = 0.73), and a favorable anatomic outcome was noted in 61.2 and 49.5% of eyes (p = 0.06), respectively. The median follow-up was 3.5 and 9 months, respectively (p < 0.0001). Susceptibilities to the common antibiotics used (vancomycin, ceftazidime, and amikacin) were comparable, with the exception of imipenem, for which the susceptibility noted was 95 and 66%, respectively (p = 0.01). Culture positivity in the TA group was seen in 72 out of 169 eyes (42.6%), while in the NTA group it was seen in 98 out of 101 eyes (97.02%; p < 0.0001).CONCLUSION:
Topical antibiotics do not give any added advantage in the management of endophthalmitis otherwise being treated with intravitreal antibiotics and standard vitrectomy techniques.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Infecções Oculares Bacterianas
/
Endoftalmite
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Ophthalmologica
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Índia