FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner.
Cell Commun Signal
; 18(1): 69, 2020 05 01.
Article
em En
| MEDLINE
| ID: mdl-32357892
ABSTRACT
Fibroblast growth factors (FGFs) via their receptors (FGFRs) transduce signals from the extracellular space to the cell interior, modulating pivotal cellular processes such as cell proliferation, motility, metabolism and death. FGF superfamily includes a group of fibroblast growth factor homologous factors (FHFs), proteins whose function is still largely unknown. Since FHFs lack the signal sequence for secretion and are unable to induce FGFR-dependent cell proliferation, these proteins were considered as intracellular proteins that are not involved in signal transduction via FGFRs. Here we demonstrate for the first time that FHF1 directly interacts with all four major FGFRs. FHF1 binding causes efficient FGFR activation and initiation of receptor-dependent signaling cascades. However, the biological effect of FHF1 differs from the one elicited by canonical FGFs, as extracellular FHF1 protects cells from apoptosis, but is unable to stimulate cell division. Our data define FHF1 as a FGFR ligand, emphasizing much greater similarity between FHFs and canonical FGFs than previously indicated. Video Abstract. (MP4 38460 kb).
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Fatores de Crescimento de Fibroblastos
/
Fatores de Crescimento de Fibroblastos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Commun Signal
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Polônia