The protective effect of Hibiscus sabdariffa calyxes extract against cypermethrin induced oxidative stress in mice.
Pestic Biochem Physiol
; 165: 104463, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-32359554
ABSTRACT
Cypermethrin (Cyp) is a kind of pyrethroids compound that is broadly used against different species of insects and pests. Cyp can also elicit a range of neurotoxic, immunotoxic, genotoxic and reproductive toxic effects on various experimental organisms. The aim of this study was to evaluate the protective effects of Hibiscus sabdariffa against the toxicity damage induced by Cyp exposure. The Hibiscus sabdariffa calyxes extract was given to mice (200-500â¯mg/kg bw). The mice, which were treated with Cyp and Hibiscus sabdariffa, were divided into six groups of six mice each. Groups I, IV and VI were used as control and groups II CYP control (20â¯mg/kg body weight)., groups III and V were treated with Hibiscus sabdariffa extract (200 and 500â¯mg/kg body weight) plus (20â¯mg/kg body weight) for 21â¯days Furthermore, HPLC was used to identify the compound fraction. This result showed Cyp -induced biochemical changes in all organs of mice. Cyp caused decreased CAT activity, inhibition of AChE activity and increased the levels of H2O2 and MDA in brain, heart, liver and kidney. Hibiscus sabdariffa exhibited antioxidant effect and significantly attenuated the neurotoxicity of Cyp. Hibiscus sabdariffa exhibits neuroprotective effects and can be an effective and novel alternative approach to reduce the risk caused by pyrethroid compound.
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Base de dados:
MEDLINE
Assunto principal:
Piretrinas
/
Hibiscus
Limite:
Animals
Idioma:
En
Revista:
Pestic Biochem Physiol
Ano de publicação:
2020
Tipo de documento:
Article