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Design, synthesis and biological activity of novel 2,3,4,5-tetra-substituted thiophene derivatives as PI3Kα inhibitors with potent antitumor activity.
Liao, Weike; Wang, Zhongyuan; Han, Yufei; Qi, Yinliang; Liu, Jiaan; Xie, Juan; Tian, Ye; Lei, Qiancheng; Chen, Rui; Sun, Ming; Tang, Lei; Gong, Guowei; Zhao, Yanfang.
Afiliação
  • Liao W; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, PR China.
  • Wang Z; Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, 550002, PR China.
  • Han Y; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang, 110016, PR China.
  • Qi Y; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang, 110016, PR China.
  • Liu J; Department of Chemistry, University of Massachusetts-Amherst, Massachusetts, 01003, United States.
  • Xie J; Department of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, 550002, PR China.
  • Tian Y; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang, 110016, PR China.
  • Lei Q; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, PR China.
  • Chen R; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, PR China.
  • Sun M; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang, 110016, PR China.
  • Tang L; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D, Guizhou Medical University, Guiyang, 550004, PR China. Electronic address: tlei1974@hotmail.com.
  • Gong G; Department of Bioengineering, Zunyi Medical University, Zhuhai Campus, Zhuhai, 519041, Guangdong, PR China. Electronic address: sammyld@163.com.
  • Zhao Y; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang, 110016, PR China. Electronic address: yanfangzhao@126.com.
Eur J Med Chem ; 197: 112309, 2020 Jul 01.
Article em En | MEDLINE | ID: mdl-32375077
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Inibidores de Fosfoinositídeo-3 Quinase / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiofenos / Inibidores de Fosfoinositídeo-3 Quinase / Antineoplásicos Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article