Enantioselective Ni-Catalyzed Electrochemical Synthesis of Biaryl Atropisomers.
J Am Chem Soc
; 142(22): 9872-9878, 2020 06 03.
Article
em En
| MEDLINE
| ID: mdl-32392046
ABSTRACT
A scalable enantioselective nickel-catalyzed electrochemical reductive homocoupling of aryl bromides has been developed, affording enantioenriched axially chiral biaryls in good yield under mild conditions using electricity as a reductant in an undivided cell. Common metal reductants such as Mn or Zn powder resulted in significantly lower yields in the absence of electric current under otherwise identical conditions, underscoring the enhanced reactivity provided by the combination of transition metal catalysis and electrochemistry.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China