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Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum.
Gutierrez-Cardo, Antonio; Lillo, Eugenia; Murcia-Casas, Belén; Carrillo-Linares, Juan Luis; García-Argüello, Francisco; Sánchez-Sánchez, Purificación; Rodriguez-Morata, Alejandro; Aranda, Isabel Baquero; Sánchez-Chaparro, Miguel Ángel; García-Fernández, María; Valdivielso, Pedro.
Afiliação
  • Gutierrez-Cardo A; Molecular Image Unit, Nuclear Medicine, Fundación General de la Universidad de Málaga, 29010 Málaga, Spain.
  • Lillo E; Department of Medicine and Dermatology, University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain.
  • Murcia-Casas B; Molecular Image Unit, Nuclear Medicine, Fundación General de la Universidad de Málaga, 29010 Málaga, Spain.
  • Carrillo-Linares JL; Internal Medicine Unit, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.
  • García-Argüello F; Internal Medicine Unit, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.
  • Sánchez-Sánchez P; Molecular Image Unit, Radiopharmacy, Fundación General de la Universidad de Málaga, 29010 Málaga, Spain.
  • Rodriguez-Morata A; Department of Medicine and Dermatology, University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain.
  • Aranda IB; Unit of Angiology and Vascular Surgery, Hospital Quirón, 29004 Málaga, Spain.
  • Sánchez-Chaparro MÁ; Unit of Ophtalmology, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain.
  • García-Fernández M; Department of Medicine and Dermatology, University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain.
  • Valdivielso P; Department of Human Physiology, University of Málaga, and Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain.
J Clin Med ; 9(5)2020 May 08.
Article em En | MEDLINE | ID: mdl-32397252
ABSTRACT
Pseudoxanthoma elasticum (PXE) is a genetic disease characterized by the calcification of elastin fibers. Our aim was to quantify vascular calcification in the arteries and the deposition of 18F-sodium-fluoride (18F-NaF) in the skin and vessel walls with positron emission tomography/computed tomography. This was an observational study including 18 patients with PXE. Vascular calcification was measured in Agatston units, and deposition in the skin and vessel walls was shown using target-to-background ratio (TBR). Severity of the disease was scored by Phenodex. We found higher vascular calcification in the popliteal, femoral, and aortic arch vessels compared to other vascular regions; however, the uptake of radiotracer was the highest in the aorta and femoral arteries. In the skin, the highest uptake was observed in the neck and the axillae. There was no significant association between 18F-NaF deposition in the arteries or skin and the global Phenodex score. In contrast, the Phenodex score was significantly associated in univariate analyses with the averaged vascular calcium score (p < 0.01). In the neck, patients with higher skin Phenodex scores exhibited higher radiotracer uptake. As a conclusion, because vascular calcification is physiological, our data suggested that the detection of cutaneous (neck) 18F-NaF deposits might serve to monitor the calcification process in the short-term for patients with PXE.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Observational_studies Idioma: En Revista: J Clin Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Observational_studies Idioma: En Revista: J Clin Med Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Espanha