Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats.

Yao, Li; Yang, Yu-Xia; Cao, Hui; Ren, Huan-Huan; Niu, Zheng; Shi, Ling

Yao, Li; Yang, Yu-Xia; Cao, Hui; Ren, Huan-Huan; Niu, Zheng; Shi, Ling.

Afiliação

Yao L; Department of Medicinal Chemistry and Natural Medicine Chemistry, Department of Pharmacognosy, College of Pharmacy, Harbin Medical University, Harbin 150081, China; State-Province Key Laboratory of Biomedicine-Pharmaceutics of China, Harbin Medical University, Harbin 150081, China. Electronic addres
Yang YX; Department of Medicinal Chemistry and Natural Medicine Chemistry, Department of Pharmacognosy, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Cao H; Department of Medicinal Chemistry and Natural Medicine Chemistry, Department of Pharmacognosy, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Ren HH; Department of Medicinal Chemistry and Natural Medicine Chemistry, Department of Pharmacognosy, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Niu Z; Department of Medicinal Chemistry and Natural Medicine Chemistry, Department of Pharmacognosy, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Shi L; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, China.

Chin J Nat Med ; 18(4): 308-320, 2020 Apr.

Article em En | MEDLINE | ID: mdl-32402408

Assuntos

Cumarínicos/farmacologia; Lisofosfolipídeos/metabolismo; Hipertensão Arterial Pulmonar/tratamento farmacológico; Esfingosina/análogos & derivados; Animais; Modelos Animais de Doenças; Regulação para Baixo; Masculino; MicroRNAs/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos; Ratos Sprague-Dawley; Esfingosina/metabolismo; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

Metabolomics; MicroRNA-21- PI3K/Akt/mTOR; Osthole; Pulmonary arterial hypertension; Sphk1/S1P; Therapeutic mechanism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esfingosina / Lisofosfolipídeos / Cumarínicos / Hipertensão Arterial Pulmonar Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Chin J Nat Med Ano de publicação: 2020 Tipo de documento: Article

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