Short- and long-term mortality following hypnotic use.
J Sleep Res
; 29(4): e13061, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32420667
ABSTRACT
Potential long-term consequences of hypnotics remain controversial. We used the prospective Swedish National March Cohort, a study based on 41,695 participants with a mean follow-up duration of 18.9 years. Logistic regression models and Cox proportional hazards models with attained age as timescale were used to assess associations of hypnotic use with short- and long-term mortality. The proportion of subjects who initiated or discontinued hypnotic use during follow-up was substantial. All groups of hypnotics were associated with increased mortality within 2 years after a first prescription, with an overall OR of 2.38 (95% CI, 2.13-2.66). The association was more pronounced among subjects younger than 60 years (OR, 6.16; 95% CI, 3.98-9.52). There was no association between hypnotic use and long-term mortality. The association between hypnotic use and increased mortality was thus restricted to a relatively short period after treatment initiation, and may be explained in terms of confounding by indication.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hipnóticos e Sedativos
/
Distúrbios do Início e da Manutenção do Sono
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Sleep Res
Assunto da revista:
PSICOFISIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Suécia