Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection.
Cell
; 181(5): 969-977, 2020 05 28.
Article
em En
| MEDLINE
| ID: mdl-32437659
ABSTRACT
SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe pneumonia in a small proportion of patients. The increased susceptibility to severe disease in the elderly and individuals with co-morbidities argues for an initial defect in anti-viral host defense mechanisms. Long-term boosting of innate immune responses, also termed "trained immunity," by certain live vaccines (BCG, oral polio vaccine, measles) induces heterologous protection against infections through epigenetic, transcriptional, and functional reprogramming of innate immune cells. We propose that induction of trained immunity by whole-microorganism vaccines may represent an important tool for reducing susceptibility to and severity of SARS-CoV-2.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
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Infecções por Coronavirus
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Coronavírus Relacionado à Síndrome Respiratória Aguda Grave
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Imunomodulação
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Betacoronavirus
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Imunidade Inata
Limite:
Animals
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Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
2020
Tipo de documento:
Article