Protein changes in synaptosomes of Huntington's disease knock-in mice are dependent on age and brain region.

Sapp, Ellen; Seeley, Connor; Iuliano, Maria; Weisman, Elizabeth; Vodicka, Petr; DiFiglia, Marian; Kegel-Gleason, Kimberly B

Sapp, Ellen; Seeley, Connor; Iuliano, Maria; Weisman, Elizabeth; Vodicka, Petr; DiFiglia, Marian; Kegel-Gleason, Kimberly B.

Afiliação

Sapp E; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA. Electronic address: esapp@mgh.harvard.edu.
Seeley C; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.
Iuliano M; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.
Weisman E; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.
Vodicka P; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.
DiFiglia M; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.
Kegel-Gleason KB; Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA.

Neurobiol Dis ; 141: 104950, 2020 07.

Article em En | MEDLINE | ID: mdl-32439598

Assuntos

Encéfalo/metabolismo; Doença de Huntington/metabolismo; Sinapses/metabolismo; Fatores Etários; Animais; Encéfalo/ultraestrutura; Modelos Animais de Doenças; Feminino; Técnicas de Introdução de Genes; Proteína Huntingtina/genética; Masculino; Camundongos Endogâmicos C57BL; Neostriado/metabolismo; Neurônios/metabolismo; Neurônios/ultraestrutura; Fosforilação; Sinapses/ultraestrutura

Palavras-chave

Cortex; David pathway analysis; Huntingtin; PDE10; Proteomics; SCN4B; Striatum; Synaptosomes; TMT mass spectrometry; Western blot

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinapses / Encéfalo / Doença de Huntington Tipo de estudo: Guideline / Prognostic_studies Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2020 Tipo de documento: Article

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