ARRB1 ameliorates liver ischaemia/reperfusion injury via antagonizing TRAF6-mediated Lysine 6-linked polyubiquitination of ASK1 in hepatocytes.

Xu, Xiaoliang; Zhang, Zechuan; Lu, Yijun; Sun, Qikai; Liu, Yang; Liu, Qiaoyu; Tian, Wenfang; Yin, Yin; Yu, Hailong; Sun, Beicheng

Xu, Xiaoliang; Zhang, Zechuan; Lu, Yijun; Sun, Qikai; Liu, Yang; Liu, Qiaoyu; Tian, Wenfang; Yin, Yin; Yu, Hailong; Sun, Beicheng.

Afiliação

Xu X; School of Medicine, Southeast University, Nanjing, China.
Zhang Z; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Lu Y; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Sun Q; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Liu Y; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Liu Q; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Tian W; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Yin Y; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Yu H; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Sun B; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

J Cell Mol Med ; 24(14): 7814-7828, 2020 07.

Article em En | MEDLINE | ID: mdl-32445435

Assuntos

Hepatopatias/etiologia; Hepatopatias/metabolismo; MAP Quinase Quinase Quinase 5/metabolismo; Traumatismo por Reperfusão/etiologia; Traumatismo por Reperfusão/metabolismo; Fator 6 Associado a Receptor de TNF/metabolismo; beta-Arrestina 1/genética; beta-Arrestina 1/metabolismo; Animais; Apoptose; Citocinas/metabolismo; Modelos Animais de Doenças; Hepatócitos/metabolismo; Imuno-Histoquímica; Mediadores da Inflamação/metabolismo; Hepatopatias/patologia; Lisina/metabolismo; Sistema de Sinalização das MAP Quinases; Masculino; Camundongos; Traumatismo por Reperfusão/patologia; Ubiquitinação

Palavras-chave

ARRB1; ASK1; Lysine 6-linked polyubiquitination; TRAF6; liver ischemia/reperfusion injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / MAP Quinase Quinase Quinase 5 / Fator 6 Associado a Receptor de TNF / Beta-Arrestina 1 / Hepatopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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