Recent advances and potential applications of human pluripotent stem cell-derived pancreatic ß cells.
Acta Biochim Biophys Sin (Shanghai)
; 52(7): 708-715, 2020 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-32445468
ABSTRACT
Diabetes mellitus is characterized by chronic high blood glucose levels resulted from deficiency and/or dysfunction of insulin-producing pancreatic ß cells. Generation of large amounts of functional pancreatic ß cells is critical for the study of pancreatic biology and treatment of diabetes. Recent advances in directed differentiation of pancreatic ß-like cells from human pluripotent stem cells (hPSCs) can provide patient-specific and disease-relevant target cells. With the improved differentiation protocols, it is now possible to generate large amounts of functional human pancreatic ß-like cells that can response to high level of glucose both in vitro and in vivo. Combined with precise genomic editing, biomedical engineering, high throughput profiling, bioinformatics, and high throughput genetic and chemical screening, these hPSC-derived pancreatic ß-like cells will hold great potentials in disease modeling, drug discovery, and cell-based therapies. In this review, we summarize the recent progress in human pancreatic ß-like cells derived from hPSCs and discuss their potential applications.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diferenciação Celular
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Células-Tronco Pluripotentes
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Diabetes Mellitus
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Células Secretoras de Insulina
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Edição de Genes
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Modelos Biológicos
Tipo de estudo:
Guideline
Limite:
Animals
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Humans
Idioma:
En
Revista:
Acta Biochim Biophys Sin (Shanghai)
Assunto da revista:
BIOFISICA
/
BIOQUIMICA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China