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Systemic but not MDSC-specific IRF4 deficiency promotes an immunosuppressed tumor microenvironment in a murine pancreatic cancer model.
Metzger, Philipp; Kirchleitner, Sabrina V; Boehmer, Daniel F R; Hörth, Christine; Eisele, Angelika; Ormanns, Steffen; Gunzer, Matthias; Lech, Maciej; Lauber, Kirsten; Endres, Stefan; Duewell, Peter; Schnurr, Max; König, Lars M.
Afiliação
  • Metzger P; Center of Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
  • Kirchleitner SV; Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.
  • Boehmer DFR; Center of Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
  • Hörth C; Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.
  • Eisele A; Center of Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
  • Ormanns S; Center of Integrated Protein Science Munich (CIPSM) and Division of Clinical Pharmacology, University Hospital, LMU Munich, Munich, Germany.
  • Gunzer M; Institute for Medical Information Processing, Biometry, and Epidemiology - IBE, Chair of Public Health and Health Services Research, LMU Munich, Munich, Germany.
  • Lech M; Pettenkofer School of Public Health, Munich, Germany.
  • Lauber K; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
  • Endres S; Institute for Experimental Immunology and Imaging, University Hospital, University Duisburg- Essen, Essen, Germany.
  • Duewell P; Leibniz Institute for Analytical Sciences - ISAS, Dortmund, Germany.
  • Schnurr M; Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany.
  • König LM; Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany.
Cancer Immunol Immunother ; 69(10): 2101-2112, 2020 Oct.
Article em En | MEDLINE | ID: mdl-32448983
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Biomarcadores Tumorais / Linfócitos T CD8-Positivos / Fatores Reguladores de Interferon / Microambiente Tumoral / Células Supressoras Mieloides Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Biomarcadores Tumorais / Linfócitos T CD8-Positivos / Fatores Reguladores de Interferon / Microambiente Tumoral / Células Supressoras Mieloides Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha