Your browser doesn't support javascript.
loading
Prognostic significance of pre- and post-operative tumour markers for patients with gastric cancer.
Lin, Jun-Peng; Lin, Jian-Xian; Ma, Yu-Bin; Xie, Jian-Wei; Yan, Su; Wang, Jia-Bin; Lu, Jun; Chen, Qi-Yue; Ma, Xin-Fu; Cao, Long-Long; Lin, Mi; Tu, Ru-Hong; Zheng, Chao-Hui; Li, Ping; Huang, Chang-Ming.
Afiliação
  • Lin JP; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
  • Lin JX; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China.
  • Ma YB; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
  • Xie JW; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China.
  • Yan S; Department of Gastrointestinal Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai Province, China.
  • Wang JB; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
  • Lu J; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China.
  • Chen QY; Department of Gastrointestinal Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai Province, China.
  • Ma XF; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
  • Cao LL; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China.
  • Lin M; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
  • Tu RH; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China.
  • Zheng CH; Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.
  • Li P; Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian Province, China.
  • Huang CM; Department of Gastrointestinal Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai Province, China.
Br J Cancer ; 123(3): 418-425, 2020 08.
Article em En | MEDLINE | ID: mdl-32451469
BACKGROUND: In clinical practice, carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 are the most common markers measured before and after surgery for gastric cancer (GC). However, which pre- or post-operative combined tumour markers (CEA and CA19-9) have more prognostic value remains unclear. METHODS: Consecutive patients undergoing a resection for GC at the Fujian Medical University Union Hospital were included as a discovery database between January 2011 and December 2014. The prognostic impact of pre- and post-operative tumour markers was evaluated using Kaplan-Meier log-rank survival analysis and multivariable Cox regression analysis. The results were then externally validated. RESULTS: A total of 735 and 400 patients were identified in the discovery cohort and in the validation cohort, respectively. Overall survival rates decreased in a stepwise manner in association with the number of pre- and post-operative positive tumour markers (both P < 0.001). Multivariable analysis revealed that the number of pre-operative positive tumour markers was an independent prognostic factor (P < 0.05). For patients with abnormal pre-operative tumour markers, normalisation of tumour markers after surgery is an independent prognostic protective factor (hazard ratio (HR) = 0.618; 95% confidence interval (CI) = 0.414-0.921), and patients with both positive post-operative tumour markers had double the risk of overall death (HR = 2.338; 95% CI = 1.071-5.101). Similar results were observed in the internal validation and external validation cohorts. CONCLUSION: Pre-operative tumour markers have a better discriminatory ability for post-operative survival in GC patients than post-operative tumour markers, and the normalisation of tumour markers after surgery was associated with better survival.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Antígenos Glicosídicos Associados a Tumores / Antígeno Carcinoembrionário / Biomarcadores Tumorais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Antígenos Glicosídicos Associados a Tumores / Antígeno Carcinoembrionário / Biomarcadores Tumorais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Br J Cancer Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China