Destabilization of ß-catenin and RAS by targeting the Wnt/ß-catenin pathway as a potential treatment for triple-negative breast cancer.

Ryu, Won-Ji; Lee, Jeong Dong; Park, Jong-Chan; Cha, Pu-Hyeon; Cho, Yong-Hee; Kim, Jee Ye; Sohn, Joo Hyuk; Paik, Soonmyung; Choi, Kang-Yell

Ryu, Won-Ji; Lee, Jeong Dong; Park, Jong-Chan; Cha, Pu-Hyeon; Cho, Yong-Hee; Kim, Jee Ye; Sohn, Joo Hyuk; Paik, Soonmyung; Choi, Kang-Yell.

Afiliação

Ryu WJ; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Korea.
Lee JD; Department of Human Biology and Genomics, Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, Korea.
Park JC; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Korea.
Cha PH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Korea.
Cho YH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Korea.
Kim JY; Department of Surgery, Yonsei University College of Medicine, Seoul, 03722, Korea.
Sohn JH; Division of Medical Oncology, Department of Internal Medicine Yonsei University College of Medicine, Seoul, 03722, Korea.
Paik S; Severance Biomedical Research Institute and Department of Medical Oncology, Yonsei University College of Medicine, Seoul, 03722, Korea. SOONMYUNGPAIK@yuhs.ac.
Choi KY; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, 03722, Korea. kychoi@yonsei.ac.kr.

Exp Mol Med ; 52(5): 832-842, 2020 05.

Article em En | MEDLINE | ID: mdl-32457491

Assuntos

Neoplasias de Mama Triplo Negativas/metabolismo; Via de Sinalização Wnt/efeitos dos fármacos; beta Catenina/metabolismo; Proteínas ras/metabolismo; Animais; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Biomarcadores; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Modelos Animais de Doenças; Receptores ErbB/metabolismo; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos; Estabilidade Proteica/efeitos dos fármacos; Tiazolidinas/farmacologia; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Neoplasias de Mama Triplo Negativas/etiologia; Neoplasias de Mama Triplo Negativas/patologia; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas ras / Beta Catenina / Via de Sinalização Wnt / Neoplasias de Mama Triplo Negativas Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Exp Mol Med Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2020 Tipo de documento: Article

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