Type 3 hypersensitivity in COVID-19 vasculitis.
Clin Immunol
; 217: 108487, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32479986
ABSTRACT
Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and new knowledge about its immunopathogenic mechanisms is deemed necessary in the attempt to reduce the death burden, globally. For the first time in worldwide literature, we provide scientific evidence that in COVID-19 vasculitis a life-threatening escalation from type 2 T-helper immune response (humoral immunity) to type 3 hypersensitivity (immune complex disease) takes place. The subsequent deposition of immune complexes inside the vascular walls is supposed to induce a severe inflammatory state and a cytokine release syndrome, whose interleukin-6 is the key myokine, from the smooth muscle cells of blood vessels.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
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Vasculite
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Doenças do Complexo Imune
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Infecções por Coronavirus
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Células Th2
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Síndrome Respiratória Aguda Grave
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Betacoronavirus
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Síndrome da Liberação de Citocina
Idioma:
En
Revista:
Clin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article