Brachial Flow-mediated Dilation and Risk of Dementia: The Cardiovascular Health Study.
Alzheimer Dis Assoc Disord
; 34(3): 272-274, 2020.
Article
em En
| MEDLINE
| ID: mdl-32483019
ABSTRACT
INTRODUCTION:
Brachial flow-mediated dilation (FMD) is a physiologic measure of endothelial function. We determined the prospective association of brachial FMD with incident dementia among older adults.METHODS:
We included 2777 Cardiovascular Health Study participants who underwent brachial FMD measurement. Incident dementia was ascertained by medication use, International Classification of Diseases-9 codes, requirement for a proxy, and death certificates and calibrated to gold-standard assessments performed in a subset of the cohort.RESULTS:
Mean participant age at time of brachial FMD measurement was 77.9 years. We identified 1650 incident dementia cases (median follow-up=10.5 y). After adjusting for age, race, sex, education, clinic site, and baseline arterial diameter, risk of dementia for participants in the highest quartile of percent brachial FMD did not differ from those in lowest quartile (hazard ratio=0.89, 95% confidence interval 0.77, 1.03).CONCLUSIONS:
Brachial FMD, measured late in life, is not associated with an increased risk of incident dementia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Velocidade do Fluxo Sanguíneo
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Artéria Braquial
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Ultrassonografia
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Demência
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Alzheimer Dis Assoc Disord
Assunto da revista:
NEUROLOGIA
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PSIQUIATRIA
Ano de publicação:
2020
Tipo de documento:
Article