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Cutaneous Involvement in Waldenström's Macroglobulinaemia.
Acta Derm Venereol ; 100(15): adv00225, 2020 Aug 17.
Article em En | MEDLINE | ID: mdl-32488284
ABSTRACT
Cutaneous involvement in Waldenström's macroglobulinaemia (WM) has been poorly characterized. To describe this involvement, a retrospective study of 19 patients with WM and cutaneous involvement of tumour B cells was performed. Twelve patients (group 1) had lymphoplasmacytic, non-transformed cutaneous proliferation, while in 7 cases (group 2) cutaneous involvement corresponded to histological transformation. In group 1, skin involvement was inaugural in 6 cases. The lesions were infiltrated plaques (83%), papules (25%) and tumours (42%). Four patients had a similar clinical picture (purplish, bilateral and symmetrical infiltration on the face). MYD88 L265P mutation was detected in the skin biopsy in all 6 cases tested. The 3-year specific survival rate was 88%. In group 2, cutaneous transformation occurred during the follow-up of the WM (71%). Lesions presented as ulcerated tumours (86%) of the trunk (57%) and lower limbs (57%). The 3-year specific survival rate was 22%. Skin involvement in WM has distinctive characteristics (e.g. clinical, histological, immunohistochemical, MYD88 L265P mutation).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Macroglobulinemia de Waldenstrom Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Humans Idioma: En Revista: Acta Derm Venereol Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Macroglobulinemia de Waldenstrom Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Humans Idioma: En Revista: Acta Derm Venereol Ano de publicação: 2020 Tipo de documento: Article