Association of diabetes with stroke and post-stroke dementia: A population-based cohort study.
Alzheimers Dement
; 16(7): 1003-1012, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32489021
ABSTRACT
INTRODUCTION:
The impact of prediabetes and diabetes on stroke and the development of dementia after a stroke remain unclear.METHODS:
A total of 2655 dementia-free participants (including a stroke-free cohort and a prevalent stroke cohort) were followed-up for 12 years. Dementia and post-stroke dementia were determined by clinical examinations and national registry data. Diabetes was ascertained via medical examination, medication use, medical records, or glycated hemoglobin (HbA1c) ≥6.5%. Prediabetes was defined as HbA1c ≥5.7% in diabetes-free participants.RESULTS:
In the stroke-free cohort, 236 participants developed ischemic stroke, and 47 developed post-stroke dementia. Diabetes was associated with ischemic stroke (hazard ratio [HR] 1.76, 95% confidence interval [CI] 1.16 to 2.67) and post-stroke dementia (HR 2.56, 95% CI 1.04 to 6.25). In the prevalent stroke cohort, diabetes was also related to dementia risk. Prediabetes was not significantly related to stroke or post-stroke dementia.DISCUSSION:
Diabetes, but not prediabetes, is associated with an increased risk of ischemic stroke and post-stroke dementia.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estado Pré-Diabético
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Demência
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Diabetes Mellitus
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AVC Isquêmico
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Alzheimers Dement
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Suécia