Unscheduled hydrations: redefining complete response in chemotherapy-induced nausea and vomiting studies.
Future Oncol
; 16(24): 1863-1872, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32543309
ABSTRACT
Breakthrough chemotherapy-induced nausea and vomiting (CINV) is nausea and/or vomiting occurring within 5 days of chemotherapy administration despite using guideline-directed prophylactic antiemetic agents. It is highly prevalent (30-40%), usually requiring immediate treatment or "rescue" medication. If breakthrough CINV occurs, antiemetic guidelines recommend using an antiemetic agent from a different class not used in prophylaxis, along with intravenous hydration and/or dexamethasone. Data supporting these guideline recommendations are limited. Importantly, costs associated with breakthrough CINV can be substantial (i.e., unscheduled hydrations). Two retrospective analyses evaluating guideline-adherent CINV prophylaxis suggest that the initial antiemetic selection may decrease breakthrough CINV. Here we review optimal CINV prophylactic strategies and introduce unscheduled hydration as a potential important surrogate for breakthrough CINV aligning with cost-effective cancer care.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vômito
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Hidratação
/
Náusea
/
Antineoplásicos
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos