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In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19.
Zhang, Xiao-Jing; Qin, Juan-Juan; Cheng, Xu; Shen, Lijun; Zhao, Yan-Ci; Yuan, Yufeng; Lei, Fang; Chen, Ming-Ming; Yang, Huilin; Bai, Liangjie; Song, Xiaohui; Lin, Lijin; Xia, Meng; Zhou, Feng; Zhou, Jianghua; She, Zhi-Gang; Zhu, Lihua; Ma, Xinliang; Xu, Qingbo; Ye, Ping; Chen, Guohua; Liu, Liming; Mao, Weiming; Yan, Youqin; Xiao, Bing; Lu, Zhigang; Peng, Gang; Liu, Mingyu; Yang, Jun; Yang, Luyu; Zhang, Changjiang; Lu, Haofeng; Xia, Xigang; Wang, Daihong; Liao, Xiaofeng; Wei, Xiang; Zhang, Bing-Hong; Zhang, Xin; Yang, Juan; Zhao, Guang-Nian; Zhang, Peng; Liu, Peter P; Loomba, Rohit; Ji, Yan-Xiao; Xia, Jiahong; Wang, Yibin; Cai, Jingjing; Guo, Jiao; Li, Hongliang.
Afiliação
  • Zhang XJ; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Qin JJ; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Cheng X; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Shen L; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Zhao YC; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Yuan Y; Department of Hepatobiliary and Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Lei F; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Chen MM; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Yang H; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Bai L; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Song X; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Lin L; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Xia M; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Zhou F; Institute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Zhou J; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • She ZG; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Zhu L; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Ma X; Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA 19004, USA.
  • Xu Q; Centre for Clinic Pharmacology, The William Harvey Research Institute, Queen Mary University of London, London, UK.
  • Ye P; Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430072, China.
  • Chen G; Department of Neurology, Wuhan First Hospital/Wuhan Hospital of Traditional Chinese and Western Medicine, Wuhan 430072, China.
  • Liu L; Department of General Surgery, Ezhou Central Hospital, Ezhou 436000, China.
  • Mao W; Department of General Surgery, Huanggang Central Hospital, Huanggang 438000, China.
  • Yan Y; Wuhan Seventh Hospital, Wuhan 430072, China.
  • Xiao B; Department of Stomatology, Xiantao First People's Hospital, Xiantao 433000, China.
  • Lu Z; Department of Neurology, The First People's Hospital of Jingmen Affiliated to Hubei Minzu University, Jingmen 448000, China.
  • Peng G; Department of Hepatobiliary and Pancreatic Surgery, Suizhou Central Hospital Affiliated to Hubei Medical College, Suizhou 441300, China.
  • Liu M; The Ninth Hospital of Wuhan City, Wuhan 430072, China.
  • Yang J; Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital and Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, China.
  • Yang L; Department of Intensive Care Unit, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, China.
  • Zhang C; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, China.
  • Lu H; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Changjiang University, Jingzhou, China.
  • Xia X; Department of Hepatobiliary Surgery, Jingzhou Central Hospital, Jingzhou, China.
  • Wang D; Department of Hepatobiliary and Pancreatic Surgery, Xianning Central Hospital, Xianning, Hubei Province, China.
  • Liao X; Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
  • Wei X; Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang BH; Department of Neonatology, Renmin Hospital of Wuhan University, Wuhan, China.
  • Zhang X; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Yang J; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China.
  • Zhao GN; Institute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Zhang P; Institute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Liu PP; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada.
  • Loomba R; NAFLD Research Center, Division of Gastroenterology and Epidemiology, University of California, San Diego, San Diego, CA, USA.
  • Ji YX; Institute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Xia J; Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: jiahong.xia@hust.edu.cn.
  • Wang Y; Departments of Anesthesiology, Physiology, and Medicine, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: yibinwang@mednet.ucla.edu.
  • Cai J; Department of Cardiology, The Third Xiangya Hospital, Central South University, Changsha 410000, China. Electronic address: caijingjing83@hotmail.com.
  • Guo J; Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine & Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China & Institute of Chinese Medicine, Guangdong Pharmaceutical University, Guangdong TCM Key Laboratory for Metabolic Diseases,
  • Li H; Department of Cardiology, Renmin Hospital, School of Basic Medical Science, Wuhan University, Wuhan, China; Institute of Model Animal, Wuhan University, Wuhan, China; Medical Science Research Center, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Hepatobiliary and Pancreatic Surg
Cell Metab ; 32(2): 176-187.e4, 2020 08 04.
Article em En | MEDLINE | ID: mdl-32592657
ABSTRACT
Statins are lipid-lowering therapeutics with favorable anti-inflammatory profiles and have been proposed as an adjunct therapy for COVID-19. However, statins may increase the risk of SARS-CoV-2 viral entry by inducing ACE2 expression. Here, we performed a retrospective study on 13,981 patients with COVID-19 in Hubei Province, China, among which 1,219 received statins. Based on a mixed-effect Cox model after propensity score-matching, we found that the risk for 28-day all-cause mortality was 5.2% and 9.4% in the matched statin and non-statin groups, respectively, with an adjusted hazard ratio of 0.58. The statin use-associated lower risk of mortality was also observed in the Cox time-varying model and marginal structural model analysis. These results give support for the completion of ongoing prospective studies and randomized controlled trials involving statin treatment for COVID-19, which are needed to further validate the utility of this class of drugs to combat the mortality of this pandemic.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Inibidores da Enzima Conversora de Angiotensina / Infecções por Coronavirus / Inibidores de Hidroximetilglutaril-CoA Redutases / Reposicionamento de Medicamentos / Anti-Hipertensivos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Inibidores da Enzima Conversora de Angiotensina / Infecções por Coronavirus / Inibidores de Hidroximetilglutaril-CoA Redutases / Reposicionamento de Medicamentos / Anti-Hipertensivos Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China