A Roadblock-and-Kill Mechanism of Action Model for the DNA-Targeting Antibiotic Ciprofloxacin.

Ojkic, Nikola; Lilja, Elin; Direito, Susana; Dawson, Angela; Allen, Rosalind J; Waclaw, Bartlomiej

Ojkic, Nikola; Lilja, Elin; Direito, Susana; Dawson, Angela; Allen, Rosalind J; Waclaw, Bartlomiej.

Afiliação

Ojkic N; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Lilja E; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Direito S; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Dawson A; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Allen RJ; SUPA, School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.
Waclaw B; Centre for Synthetic and Systems Biology, Edinburgh, United Kingdom.

Antimicrob Agents Chemother ; 64(9)2020 08 20.

Article em En | MEDLINE | ID: mdl-32601161

Assuntos

Antibacterianos; Ciprofloxacina; Antibacterianos/farmacologia; Ciprofloxacina/farmacologia; DNA; DNA Girase/genética; DNA Topoisomerase IV/genética; DNA Topoisomerases Tipo II/genética; DNA Bacteriano/genética; Escherichia coli/genética; Fluoroquinolonas; Mutação

Palavras-chave

antibiotics; computer modeling; fluoroquinolones; mechanisms of action

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ciprofloxacina / Antibacterianos Tipo de estudo: Prognostic_studies Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Reino Unido

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